Johnson Matthey Catalysts has drawn attention to its publication of two new scientific research papers.

The first, entitled Synthesis and X-Ray Structure Determination of Highly Active Pd(II), Pd(I) and Pd(0) Complexes of Di-(tert-butyl)neopentylphosphine (DTBNpP) in the Arylation of Amines and Ketones, appears in the Journal of Organic Chemistry.

It concludes that the air-stable complex Pd(n3-allyl)(DTBNpP)Cl functions as a highly efficient pre-catalyst for the arylation of amines and enolates.

Using aryl bromides and chlorides under mild conditions, the researchers witnessed yields of between 74 per cent and 98 per cent.

Thomas Colacot, R&D Manager at Johnson Matthey Catalysts, and Kevin Shaughnessy, Associate Professor and Chair of the Department of Chemistry at the University of Alabama, collaborated on the project.

Meanwhile, a review which appears in the Angewandte Chemie International Edition summarises the recent developments in metal-catalysed α-arylation of carbonyl compounds.

The main focus of the piece is assessing how the substrate scope has been expanded through the careful selection of ligand choice, pre-catalysts, bases and reaction conditions.

Sources:



Synthesis and X-ray Structure Determination of Highly Active Pd(II), Pd(I), and Pd(0) Complexes of Di(tert-butyl)neopentylphosphine (DTBNpP) in the Arylation of Amines and Ketones (01/09/10)



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