Employing supported palladium in coupling reactions can enable chemists to retain the benefits of homogeneous catalysis while maintaining the ease of heterogeneous catalyst separation, according to recent research.

The discovery in the field of scaling-up Sonogashira chemistry is outlined in a new report from a team of scientists including Andreas Szabo and Jozsef Repasi from Budapest-based research facility Ubichem Research and is published in the Journal of Organic Chemistry.

Meanwhile, a second report, co-authored by Ubichem's Tibor Soos, outlines groundbreaking research in organocatalytic work on the asymmetric Michael addition, showing how thiourea catalysts can improve efficiency in the reaction of nitromethane with chalcones with high levels of enantioselectivity.

Ubichem Research, which is a subsidiary of chemicals company Ubichem, was formed in 1995 and conducts research into pharmaceuticals at the early stages of their development.

In February of this year, Ubichem Research conducted its first regulatory audit and was subsequently granted approval for the commercial supply of cGMP Active Pharmaceutical Ingredients (APIs) by the Hungarian Institute for Pharmacy.

Source:

Ubichem catalyzes research, 30/04/07
http://www.pharmalive.com/News/index.cfm?articleid=436783&categoryid=15

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